The central nucleus is composed of two organ preparations, Corpus Pinealis suis and Glandula Thymi suis.

Corpus Pinealis suis takes effect through its hormone (melatonin), by means of which it normalizes not only the circadian rhythms, but also neuroen- docrine homeostasis, as well as controlling behavior.
It is worth noting that the preparation also contains the two precursors of melatonin: tryptophan and serotonin; the latter is known to have a role in controlling mood.

Thymus Suis modulates hypothalamus activity; it regulates the gonads and is regulated by them in return.
Acidum Phosphoricum and Sepia are two homeopathic polycrests whose Materia Medica makes them suitable for use in depressive conditions. Alfalfa and Avena sativa are used in homeopathy as “antiasthenic” and “neurotonic” agents.

The nosode Salmonella Thyphi is used for its symptomatological similarity: typhic disease determines the so-called “typhous state”, a condition char- acterized by depression, confusion and delirium